Hier finden Sie die aktuelle Studienlage zu kurzkettigen Fettsäuren und insbesondere Propionsäure (Natriumpropionat):
▪Arpaia N., Campbell C., Fan X., Dikiy S., van der Veeken J., deRoos P., Liu H., Cross J.R., Pfeffer K., Cof fer P.J., & Rudensky A.Y., 2013. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature, 504: 451–455.
▪Bachmann H.P., Fröhlich M.T., & Bisig W., 2020. Rohmilch und Rohmilchprodukte beeinflussen die menschliche Gesundheit – eine Literaturbesprechung. Agrarforschung Schweiz, 11: 124–130.
▪Bartol omaeus H., Balogh A ., Yakoub M., Homann S., Ma rko L., Hoges S., Tsvetkov D., Krannich A., Wundersitz S., Avery E.G., Haase N., Kraker K., Hering L., Maase M., Kusche-Vihrog K., Grandoch M., Fielitz J., Kempa S., Gollasch M., Zhumad ilov Z., Kozhakhmetov S ., Kushugulova A., Eckardt K. U., Dechen d R., Rump L. C., Forslund S. K., Muller D. N., Stegbauer J., & Wilck N., 2019. Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage. Circulation, 139: 1407–1421.
▪Bergman E.N., 1990. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiological Reviews, 70: 567–590.
▪Bhutia Y.D., & Ganap athy V., 2015. Short , but Smart: SCFAs Train T Ce lls in the Gut to Fight Autoimmunity in the Brain. Immunity, 43: 629–631.
▪Bouglé D., Vaghefi-Vaezzadeh N., Roland N., Bouvard G., Arhan P., Bureau F., Neuville D., & Maubois J.L., 2002. Influence of Short-Chain Fatty Acids on Iron Absorption by Proximal Colon. Scand J Gastroenterology, 37: 100 8–1011.
▪Byrne C.S., Chambers E.S., Morrison D.J., & Frost G., 2015. The role of short chain fatty acids in appetite regulation and energy homeostasis. Int. J. O bes.
(Lond), 39: 1331–13 38.
▪Canfora E.E., Jocken J.W., & Blaak E.E., 2015. Short-chain fatt y acids in control of body weight and insulin sensitivity. Nature reviews Endocrinology, 11: 577–59 1.
▪Correa- Oliveira R., Fachi J.L., Vieira A., Sato F.T., & Vinolo M.A., 2016. Regulation of immune cell function by short-chain fatt y acids. Clin Transl Immunology, 5: e73.
▪Cousin F.J., Jouan-Lanhouet S., Dimanche-Boitrel M.T., Corcos L., & Jan G., 2012. Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells. PLoS One, 7: e31892.
▪Cousin F.J., Jouan-Lanhouet S., Théret N., Brenner C., Jouan E., Le Moig-
ne-Muller G., Dimanche-Boitrel M.-T., & Jan G., 2016. The probiotic Propio-
nibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in
colorectal cancer. Oncotarget, 7: 7161–7178.
▪Cummings J.H., Pomare E.W., Branch W.J., Naylor C.P., & Macfarlane G.T., 1987. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut, 28: 1221–1227.
▪DeVadder F., Kovatcheva-Datchary P., Goncalves D., Vinera J., Zitoun C., Duchampt A ., Bäckhed F., & Mithieux G., 2014. Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits. Cell, 156: 84–96.
▪Duscha A ., Gisevius B., Hirs chberg S., Yiss achar N., Stangl G.I ., Eilers E., Bader V., Haase S., Kaisler J., David C., Schneider R.,Troisi R., Zent D., Hegelmaier T., Dokalis N., Gerstein S., Del Mare-Roumani S., Amidror S., Staszewski O., Poschmann G.. Stühler K., Hirche F., Balogh A., Kempa S., Träger P., Zaiss M. M., Holm J. B., Massa M. G., Nielsen H. B., Faissner A., Lukas C., Gatermann S. G., Scholz M., Przuntek H., Pri nz M., Forslund S. K. , Winklhofer K. F., Müller D. N., Linker R. A., Gold R., & Haghikia A ., 2020. Propionic Acid Shapes the Multiple S clerosis Disease Co urse by an Immunomo dulatory Mech anism. Cell, 180: 10 67–1080 .
▪EFSA, Panel on Food additives and Nutrient Sources added to Food, (2014. Scientif ic Opinion on the re- evaluation of propionic acid (E 280), sodium propionate (E 281), calc ium propionate (E 282) a nd potassium propi onate (E 283) as food additives. EFSA Journal, 12: 3779.
▪Enders G., 2017. Darm mit Charme. Ullstein Buchverlage, ISBN 978-3-550-0818 4
▪Foligné B., Breton J., Mater D., & Jan G., 2013. Tracking the microbiome func-tionality: focus on Propionibacterium species. Gut, 62: 12 27–1228.
▪Foligne B., Deutsch S.M., Breton J., Cousin F.J., Dewulf J., Samson M., Pot B., & Jan G., 2010. Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo. Appl Environ Micro-biol, 76: 8259–8264.
▪Ganapathy V., Thangaraju M., Prasad P.D., Martin P.M., & Singh N., 2013. Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. Curr. Opinion Pharmacology, 13: 869 – 874.
▪Gonzalez A., Stombaugh J., Lozupone C., Turnbaugh P.J., Gordon J.I., & Knight R., 2011. The mind-body-microbial continuum. Dialog Clin Neurosci, 13: 55– 62.
▪Haghikia A., Jorg S., Duscha A., Berg J., Manzel A., Waschbisch A., Hammer A., Lee D.H., May C., Wilck N., Balogh A., Ostermann A. I., Schebb N. H., Akkad D. A., Grohme D. A., Kleinewietfeld M., Kempa S., Thone J., Demir S., Muller D. N., Go ld R., & Linker R. A. , 2015 . Dietary Fatt y Acids Directl y Impact Central Nervous System Autoimmunity via the Small Intestine. Immunity, 43: 817–8 29.
▪Hung C. C., Garner C. D., Slauch J. M., Dwyer Z. W., Lawhon S. D., Frye J. G., McClelland M., Ahmer B. M. M., & Altier C., 2013. The intestinal fatty acid propionate inhibits Salmonella invasion through the post-translational control of HilD. Mol Microbiol, 87: 1045–1060.
▪Kelly C. J., Zheng L., Campbell E. L., Saeedi B., Scholz C. C., Bayless A. J., Wilson K. E., Glover L. E., Kominsky D. J., Magnuson A., Weir T. L., Ehrentraut S. F., Pickel C., Kuhn K. A., Lanis J. M., Nguyen V., Taylor C. T., & Colgan S. P., 2015. Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe,
17: 662–671.
▪Kim M., Qie Y., Park J., & Kim C .H., 2016. Gut Microbial M etabolites Fuel H ost Antibody Responses. Cell Host Microbe, 20: 202–214.
▪Klucker E., 20 19 . Einfluss der Th1- und Th2-Zelle n in der frühen Immu nmaturation auf allergische Erkrankungen im Kindesalter: Schutz vor allergischer Sensibilisierung bei Bauernhofexposition. Dissertation Ludwig-Maximilians-Universität München, ediss:24463.
▪Lan A., Bruneau A., Bensaada M., Philippe C., Bellaud P., Rabot S., & Jan G., 2008. Increased induction of apoptosis by Propionibacterium freudenreichii TL133 in colonic mucosal crypt s of human microbiota-associated rats treated with 1,2-dimethylhydrazine. Br J Nutr, 100: 1251–1259 .
▪Le Marechal C., Peton V., Ple C., Vroland C., Jardin J., Briard-Bion V., Durant G., Chuat V., Loux V., Foligne B., Deutsch S. M., Falentin H., & Jan G., 2014. Data from an integrative approach decipher the surface proteome of Propionibacterium freudenreichii. Data Brief, 1: 46–50.
▪Macia L., Thorburn A. N., Binge L. C., Marino E., Rogers K. E., Maslowski K. M., Vieira A. T., Kranich J., & Mackay C. R., 2012. Microbial influences on epithelia l integrity and im mune function as a b asis for inflammator y diseases.
Immunol Rev, 245: 164–176 .
▪Marques F., Nels on E., Chu P. Y., H orlock D., Fiedler A ., Ziemann M., Tan J., Kuruppu S., Rajapakse N., El-Osta A., Mackay C. R., & Kaye D., 2016. High Fibre Diet and Ace tate Supplement ation Change the Gu t Microbiota and Pr event the Development of Hypertension and Heart Failure in DOCA-Salt Hypertensive Mice. Circulation, 135: 964–977.
▪Mayer E.A., 2011. Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci, 12: 453– 466.
▪Natarajan N., Hori D., Flavahan S., Steppan J., Flavahan N. A., Berkowitz D. E., & Pluznick J. L., 2016. Microbial short chain fatt y acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41. Physiol. Genomics, 48: 826–834